Corinne Nielsen
Recent News
Education
Ph.D., Harvard University
Research Interests
- Lab: Irvine 303/316
- Genetic regulation of mammalian neurovascular development, physiology and pathophysiology
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Representative Publications
Nakisli, S., Fanelli, K., LaComb, J., Arnold, L.J., and Nielsen, C.M. (2025). CNS resident macrophages exhibit region-specific states and immunogenic response during Rbpj-deficient brain arteriovenous malformation. Scientific Reports 15: 3932. DOI: 10.1038/s41598-025-86150-4. PMID: 39890825
Nakisli, S., Lagares, A., Nielsen, C.M.* and Cuervo, H.* (2023). Pericytes and vascular smooth muscle cells in central nervous system arteriovenous malformations. Front Physiol 14. doi: 10.3389/fphys.2023.1210563. PMID: 37601628
Adhicary, S., Fanelli, K., Nakisli, S., Ward, B., Pearce, I. and Nielsen, C.M. (2023). Rbpj deficiency disrupts vascular remodeling via abnormal Apelin and Cdc42 activity in brain arteriovenous malformation. Stroke 54. doi: 10.1161/STROKEAHA.122.041853
Nielsen, C.M.*, Zhang, X.*, Rangor, K., Wang, S. and Wang, R.A. (2022). Endothelial Rbpj normalizes Notch4-induced brain arteriovenous malformation in mice. J Exp Med 220(2): e20211390. doi: 10.1084/jem.20211390. PMID: 36441145. *Equal contribution
Adhicary, S., Nakisli, S., Fanelli, K. and Nielsen, C.M. (2022). Neurovascular development. Encyclopedia of Child and Adolescent Health. Elsevier Publishing. ISBN: 978-0-12-818872-9. doi: 10.1016/B978-0-12-818872-9.00106-0
Song, J., Qian, Y, Evers, M., Nielsen, C.M. and Chen, X. (2022). Cancer stem cell formation induced and regulated by extracellular ATP and stanniocalcin-1 in human lung cancer cells and tumors. Int J Mol Sci 23: 14770. doi: 10.3390/ijms232314770.
Selhorst, S.*, Nakisli, S.*, Kandalai, S., Adhicary, S. and Nielsen, C.M. (2022). Pathological pericyte expansion and impaired endothelial cell-pericyte communication in endothelial Rbpj deficient brain arteriovenous malformation. Frontiers in Human Neuroscience. doi: 10.3389/fnhum.2022.974033. PMID: 36147294. *Equal contribution
Chapman, A.D., Selhorst, S., LaComb, J., LeDantec-Boswell, A., Wohl, T.R., Adhicary, S. and Nielsen, C.M. (2022). Endothelial Rbpj is required for cerebellar morphogenesis and motor control in the early postnatal mouse brain. Cerebellum doi: 10.1007/s12311-022-01429-w. PMID: 35716334
Nielsen, C.M.*, Qian, Y*., Adhicary, S., Li, Y., Shriwas, P., Wang, X., Bachmann, L. and Chen, X. (2021). ATP internalization, mediated by macropinocytosis and examined by fluorescence microscopy, in human tumor cells and in tumor-xenografted mice. J Vis Expts. doi: 10.3791/62768. PMID: 34279488. *Equal contribution
Shriwas, P., Roberts, D., Li, Y., Wang, L., Qian, Y., Bergmeier, S., Hines, J., Adhicary, S., Nielsen, C. and Chen, X. (2021). A small molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism. Cancer & Metabolism 9(14). PMID: 33771231nie
Cuervo, H., Nielsen, C.M., Simonetto, D.A., Ferrell, L., Shah, V.H. and Wang, R.A. 2016. Endothelial Notch signaling is essential to prevent hepatic vascular malformation in mice. Hepatology 64(4):1302-1316.
Nielsen, C.M., Huang, L., Murphy, P.A., Lawton, M.T. and Wang, R.A. 2016. Mouse models of cerebral arteriovenous malformations. Stroke 47:293-300.
Murphy, P.A., Kim, T.N., Huang, L., Nielsen, C.M., Lawton, M.T., Adams, R.H., Schaffer, C.B. and Wang, R.A. 2014. Constitutively active Notch4 elicits brain arteriovenous malformations through enlargement of capillary-like vessels. Proceedings of the National Academy of Sciences USA 111:18007-18012.
Nielsen, C.M., Cuervo, H., Ding, V.W., Kong, Y., Huang, E.J. and Wang, R.A. 2014. Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice. Development 141:3782-3792.
Nielsen, C.M. and Dymecki, S.M. 2010. Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Developmental Biology 340:430-437.